生物可降解锌基合金材料的研究进展

Wang Heng, Yang Kang, Yiming Ma, Xu Lin
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摘要

作为生物医学用途的生物降解材料,人们对镁合金和铁合金进行了大量的研究。然而,这两种材料都有明显的缺点。镁合金在人类环境中降解过快,降解速度不均匀,导致其力学性能迅速下降,不能提供足够的支撑或固定能力。铁合金由于其降解产物具有良好的保护作用,降解速度非常慢,造成了与不可降解材料类似的问题。在这种情况下,近年来人们经常提到锌合金,因为锌是人体必需的微量元素,锌的标准电位介于Mg和Fe之间,因此其降解率极佳。同时,锌基合金已成为继镁合金、铁合金之后的一种新型生物可降解生物医学材料,在心血管支架、骨植入物及内固定装置、胃肠吻合器等方面得到了广泛的应用。目前,生物可降解生物医用锌基合金材料还没有系统的研究成果,研究方向包括成分设计、加工制备、降解原理、生物相容性、力学性能等各个方面。本文综述了锌基合金材料的性能,并与其他典型合金进行了比较,指出了今后的发展方向
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Research Progress on Biodegradable Zn-Based Alloy Materials
: As biodegradable materials for biomedical purposes, people have done a lot of research on Mg alloy and Fe alloy. However, both types of materials have obvious shortcomings. Mg alloy degrades too rapid and the inhomogeneity degradation rate in the human environment, resulting in its mechanical properties rapidly declining and it cannot provide adequate support or fixing capacity. Fe alloy has a very slow degradation rate due to the good protective effect of its degradation products, resulting in similar problems to non-degradable material. In this situation, Zn alloys are often mentioned in recent years, because Zn is an essential trace element for the human body, and the standard potential of Zn is between Mg and Fe, so its degradation rate is excellent. At the same time, Zn-based alloy has become a new biodegradable biomedical material after Mg alloy and Fe alloy, and has been widely used in cardiovascular stents, bone implants and internal fixation devices, and gastrointestinal staplers. At present, there is no systematic research result on biodegradable biomedical Zn-based Alloy Materials, the research interests include composition design, processing and preparation, degradation principle, biocompatibility, mechanical properties in all aspects. This article reviewed the properties of Zn-based Alloy Materials compared with other typical alloys and pointed out the future development direction
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