Elanchezhian B. , Manivannan N. , Arumugam R. , Selvanathan G.
{"title":"杂环二氧杂氮螺衍生物的合成、表征、抗氧化和抗菌评估","authors":"Elanchezhian B. , Manivannan N. , Arumugam R. , Selvanathan G.","doi":"10.1080/10406638.2023.2233663","DOIUrl":null,"url":null,"abstract":"<div><p>The reaction of propane-1, 2-diol, and mercapto ethanol with piperidone yielded a series of novel heterocyclic dioxaaza spiro derivatives of piperidone. IR, Mass, <sup>1</sup>H, <sup>13</sup>C, HOMOCOSY, and NOESY were used to characterize the synthesized compounds. The compounds were tested for antibacterial, antifungal, and antioxidant activity, as well as drug-likeness in a computer simulation, with respect to bioavailability. The compounds exhibited good antioxidant, antibacterial, and antifungal activity. All of the tested compounds are likely to have sufficient oral bioavailability, as per to in-silico studies, all the parameters were consistent with Lipinski’s five rules. These findings support the view that the synthesized compounds hold promise for drug discovery in the treatment of diseases caused by the pathogens studied.</p></div>","PeriodicalId":20303,"journal":{"name":"Polycyclic Aromatic Compounds","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Characterization, Antioxidant and Antimicrobial Evaluation of Heterocyclic Dioxaaza Spiro Derivatives\",\"authors\":\"Elanchezhian B. , Manivannan N. , Arumugam R. , Selvanathan G.\",\"doi\":\"10.1080/10406638.2023.2233663\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The reaction of propane-1, 2-diol, and mercapto ethanol with piperidone yielded a series of novel heterocyclic dioxaaza spiro derivatives of piperidone. IR, Mass, <sup>1</sup>H, <sup>13</sup>C, HOMOCOSY, and NOESY were used to characterize the synthesized compounds. The compounds were tested for antibacterial, antifungal, and antioxidant activity, as well as drug-likeness in a computer simulation, with respect to bioavailability. The compounds exhibited good antioxidant, antibacterial, and antifungal activity. All of the tested compounds are likely to have sufficient oral bioavailability, as per to in-silico studies, all the parameters were consistent with Lipinski’s five rules. These findings support the view that the synthesized compounds hold promise for drug discovery in the treatment of diseases caused by the pathogens studied.</p></div>\",\"PeriodicalId\":20303,\"journal\":{\"name\":\"Polycyclic Aromatic Compounds\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polycyclic Aromatic Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1040663823016640\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polycyclic Aromatic Compounds","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1040663823016640","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis, Characterization, Antioxidant and Antimicrobial Evaluation of Heterocyclic Dioxaaza Spiro Derivatives
The reaction of propane-1, 2-diol, and mercapto ethanol with piperidone yielded a series of novel heterocyclic dioxaaza spiro derivatives of piperidone. IR, Mass, 1H, 13C, HOMOCOSY, and NOESY were used to characterize the synthesized compounds. The compounds were tested for antibacterial, antifungal, and antioxidant activity, as well as drug-likeness in a computer simulation, with respect to bioavailability. The compounds exhibited good antioxidant, antibacterial, and antifungal activity. All of the tested compounds are likely to have sufficient oral bioavailability, as per to in-silico studies, all the parameters were consistent with Lipinski’s five rules. These findings support the view that the synthesized compounds hold promise for drug discovery in the treatment of diseases caused by the pathogens studied.
期刊介绍:
The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.