Impact of Male Reproductive Hormones on Sperm Activity via Regulation of Semen Antioxidant Levels

New relationship between Hormones and Antioxidants has been proposed. The levelsof several hormones correlate well with different Antioxidants activities in different tissues.The study conducted to find a relationship between serum male reproductive hormonesandsemen Antioxidantlevels and sperm activity.Samples of infertile group consist of Asthenozoospermia ASZ (n=31) and healthy fertile menas a control (n=24). The patients have been selected and examined according to (W.H.O2010) semen analysis manual criteria. In addition th biochemical analysis of seminal plasmaincluding (Total antioxidant capacity TAC, Glutathione Reductase GRD, glutathione andMalondialdehyde MDA) and serum (LH, FSH and Testosterone) were assayed for eachsample.Results show a decrease in TAC level of ASZ group as compared to control (439.1±207.9 and834.5±253.7 μM), and a significant decrease in seminal glutathione levels of (127.77±59.08and 174.12±61.25 μM) respectively, and show an increase in MDA level (131.45±119.61 and44.13±13.07 nmol/ml) respectively, while no significant difference in GRD level(24.00±17.69 and 16.02± 9.66 U/mL) respectively. Also there is an increase in LH and FSHhormones level (5.26±2.92, 5.81±5.46 mIU/ml), in ASZ as compared to control (2.29±1.15,1.970±1.547 IU/ml) respectively, and no significance difference in the testosterone level(5.60±1.92 and 4.35±1.65 ng/mL).