在胰腺癌中，抗bag3治疗对肿瘤相关巨噬细胞的消耗是对PD-1阻断的补充

Annals of Pancreatic Cancer Pub Date : 2018-10-01 DOI:10.21037/APC.2018.10.01

Yi Sun, R. Torphy, Yuwen Zhu

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引用次数: 0

摘要

发表在Gut杂志上的新文献表明，联合使用抗BAG3单抗和抗pd -1单抗治疗胰腺癌可以消除肿瘤相关巨噬细胞(tam)，增加肿瘤浸润CD8+ T细胞，并导致肿瘤生长抑制(1)。这些发现突出了BAG3 (bcl -2相关的thanogene 3)作为治疗靶点与免疫检查点阻断联合治疗胰腺癌的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Depletion of tumor associated macrophages by anti-BAG3 treatment complements PD-1 blockade in pancreatic cancer

New literature published in Gut has shown that combined treatment of anti-BAG3 mAb and anti-PD-1 mAb in pancreatic cancer can eliminate tumor-associated macrophages (TAMs), increase tumor infiltrating CD8+ T cells and result in tumor growth suppression (1). These findings highlight the potential of BAG3 (Bcl-2-associated athanogene 3) as a therapeutic target in conjunction with immune checkpoint blockade in the treatment of pancreatic cancer.

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来源期刊

Annals of Pancreatic Cancer

CiteScore

0.90

自引率

0.00%

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