纳米医学改善给药效果[撤回]

M. Joshi, G. Tiwari, R. Tiwari, B. Srivastava
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引用次数: 2

摘要

纳米医学概念的早期起源源于一个有远见的想法,即可以设计、制造微型纳米机器人和相关机器,并将其引入人体,在分子水平上进行细胞修复。今天,纳米医学已经向数百个不同的方向发展,每一个方向都体现了一个关键的洞察力,即在分子尺度上构建材料和设备的能力可以为医学研究和实践带来巨大的直接利益。纳米技术与生物学和医学的结合催生了一个新的科学领域——纳米医学。对药物、治疗和诊断试剂的合理递送和靶向性的研究是纳米医学项目的前沿。这包括识别与特定临床条件相关的精确靶标(细胞和受体),以及选择适当的纳米载体,以实现所需的反应,同时最大限度地减少副作用。单核吞噬细胞、树突状细胞、内皮细胞和肿瘤(肿瘤细胞以及肿瘤新生血管)是主要靶点。纳米医学的最终目标是开发精心设计的纳米工具,用于预防、诊断和治疗许多疾病。今天,纳米医学已经向数百个不同的方向发展,每一个方向都体现了一个关键的洞察力,即在分子尺度上构建材料和设备的能力可以为医学研究和实践带来巨大的直接利益。
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Nanomedicine to improve drug delivery outcomes [Retracted]
The early genesis of the concept of nanomedicine sprang from the visionary idea that tiny nanorobots and related machines could be designed, manufactured, and introduced into the human body to perform cellular repairs at the molecular level. Nanomedicine today has branched out in hundreds of different directions, each of them embodying the key insight that the ability to structure materials and devices at the molecular scale can bring enormous immediate benefits in the research and practice of medicine. The integration of nanotechnology with biology and medicine has given birth to a new field of science called Nanomedicine. Research into the rational delivery and targeting of pharmaceutical, therapeutic, and diagnostic agents is at the forefront of projects in nanomedicine. These involve the identification of precise targets (cells and receptors) related to specific clinical conditions and choice of the appropriate nanocarriers to achieve the required responses while minimizing the side effects. Mononuclear phagocytes, dendritic cells, endothelial cells, and cancers (tumor cells as well as tumor neovasculature) are key targets. The ultimate goal of nanomedicine is to develop well-engineered nanotools for the prevention, diagnosis, and treatment of many diseases. Nanomedicine today has branched out in hundreds of different directions, each of them embodying the key insight that the ability to structure materials and devices at the molecular scale can bring enormous immediate benefits in the research and practice of medicine.
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