{"title":"某些降压药的评价","authors":"J.P. Buckley, M.L. Jacquart, J.A. Bianculli, R.K. Bickerton , W.J. Hudak , F.M. Schalit , J.J. Defeo","doi":"10.1002/jps.3030490907","DOIUrl":null,"url":null,"abstract":"<div><p>Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 9","pages":"Pages 586-589"},"PeriodicalIF":0.0000,"publicationDate":"1960-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490907","citationCount":"1","resultStr":"{\"title\":\"An Evaluation of Certain Hypotensive Agents IV.*\",\"authors\":\"J.P. Buckley, M.L. Jacquart, J.A. Bianculli, R.K. Bickerton , W.J. Hudak , F.M. Schalit , J.J. Defeo\",\"doi\":\"10.1002/jps.3030490907\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.</p></div>\",\"PeriodicalId\":100839,\"journal\":{\"name\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"volume\":\"49 9\",\"pages\":\"Pages 586-589\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1960-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/jps.3030490907\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Pharmaceutical Association (Scientific ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S009595531536296X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S009595531536296X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
在麻醉的大鼠和狗身上对某些二季化哌啶衍生物和几种双叔胺进行了评价。最有效的降压药是:3-氨基苯酚丙基n -甲基哌啶二甲基醚(JB-643)、2-morpholinoethyl n -甲基哌啶二甲基溴(JB-654)和-(3-二乙基氨基-1-丙基)- n -甲基哌啶二甲基溴(JB-579)。将化合物JB-643和JB-654口服给未麻醉的狗，可产生持续超过11小时的显著降压反应。
Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.
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