糖尿病足病管理的生物打印技术:新兴应用、挑战和前景

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-07-31 DOI:10.36922/ijb.0142
Fan Xu, Shunli Rui, Cheng Yang, Xiaoyan Jiang, Wei Wu, Xianlun Tang, David G Armstrong, Yu Ma, Wu Deng
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引用次数: 0

摘要

大多数传统疗法在修复糖尿病足溃疡(DFUs)患者慢性炎症引起的复杂伤口方面存在局限性。近年来,为了响应更多生物技术战略的需求,生物打印在再生领域得到了探索。然而,复杂模型的结构和适当生物材料的选择仍然存在挑战。本文就生物打印技术在慢性糖尿病足创面愈合中的应用现状进行综述。首先,介绍了生物打印在生产皮肤等效物以促进伤口愈合方面最常见的应用;其次,讨论了生物打印在治疗慢性和难以愈合的DFU伤口方面的功能改进;最后,总结了生物打印在解决糖尿病足病独特特征方面的应用。此外,本工作总结了材料选择和三维(3D)生物打印与各种加速伤口愈合的仿生策略之间的相关性。新的生物技术工具,如用于开发未来生物打印的新生物材料的类器官也进行了讨论。
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Bioprinting technology for the management of diabetic foot disease: Emerging applications, challenges, and prospects
Most conventional therapies have limitations in the repair of complex wounds caused by chronic inflammation in patients with diabetic foot ulcers (DFUs). In response to the demand for more biotechnology strategies, bioprinting has been explored in the regeneration field in recent years. However, challenges remain regarding the structure of complex models and the selection of proper biomaterials. The purpose of this review is to introduce the current applications of bioprinting technology in chronic diabetic foot wound healing. First, the most common application of bioprinting in producing skin equivalents to promote wound healing is introduced; second, functional improvements in the treatment of chronic and difficult-to-heal DFU wounds facilitated by bioprinting applications are discussed; and last but not least, bioprinting applications in addressing unique diabetic foot disease characteristics are summarized. Furthermore, the present work summarizes material selection and correlations between three-dimensional (3D) bioprinting and a variety of biomimetic strategies for accelerating wound healing. Novel, biotechnological tools such as organoids for developing new biomaterials for bioprinting in the future are also discussed.  
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
期刊最新文献
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