新型可降解月桂酸铜(II)表面活性剂的杀菌活性及表征

Q2 Pharmacology, Toxicology and Pharmaceutics Open Medicinal Chemistry Journal Pub Date : 2018-10-26 DOI:10.2174/1874842201805010089
A. Sharma, M. Saxena, Rashmi Sharma
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引用次数: 6

摘要

胶体系统在自然界中极为普遍,在我们的日常生活中具有重要的实际意义。表面活性剂在现代工程和药用肥皂中非常重要,由于在溶液中形成胶束和高表面活性(即其分子形成表面吸附层的能力),肥皂与不同配体的配合物几乎用于国民经济的所有部门。为此,我们首次考虑了铜表面活性剂/皂的合成及其N/S给体的络合。本文报道了月桂酸铜硫脲的常规合成方法,并对其进行了元素分析、红外光谱、核磁共振、ESR等表征。为了了解这些表面活性剂/复合物的生物学特性及其作为抗真菌剂的应用,人们还在生物化学领域进行了研究。为了了解它们的生物学特性,特别是它们的杀真菌活性,采用P.D.A.(马铃薯葡萄糖琼脂)技术,用不同浓度的月桂酸铜皂及其硫脲络合物对交替曲霉、烟曲霉和黑曲霉进行了测定。对这些化合物的生物学研究也将提供有关其工业利用的重要信息。
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Fungicidal Activities and Characterization of Novel Biodegradable Cu (II) Surfactants Derived from Lauric Acid
Colloidal systems are extremely widespread in nature and are of great practical importance in our daily life. Surfactants are very important in modern engineering and pharmaceutical soap and the complexes of soaps with different ligands are used in almost all sectors of national economy due to the formation of micelles in solutions and high surface activity i.e. the ability of their molecules to form surface adsorption layers. For this purpose, first time we thought about the synthesis of copper surfactants/soaps and their complexation by N/S donor ligands. In this paper, we report the synthesis of copper laurate thiourea by conventional methods and its characterization by elemental analysis, IR, NMR, ESR spectral studies. In order to understand their biological aspects and application of these surfactants/complexes as antifungal agents, astudy has also been conducted in the field of biochemistry. In order to understand their biological aspects with special reference to fungicidal activities, three different fungi namely Aspergillus alternaria, Aspergillus Fumigatus and Aspergillus niger were taken and tested by different concentrations of copper laurate soap and its thiourea complex by P.D.A. (Potato dextrose agar) technique. Biological studies of these compounds will also provide an important account of information about their industrial utilization.
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来源期刊
Open Medicinal Chemistry Journal
Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.40
自引率
0.00%
发文量
4
期刊最新文献
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