宫内授精后不孕的女性因素及其妊娠结局:孟加拉国790例的经验

Shafeya Khanam, R. Khanam, Muqsuda Ashraf Shuvro, Morium Faruque Shati, Trifa Obayed
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摘要

背景:一些女性因素与不孕症的病因有关。目的:本研究的目的是评估与不孕相关的女性因素及其宫内人工授精后的妊娠结局。方法:这项前瞻性队列研究于2012年1月至2017年12月在孟加拉国达喀市的一家私人不孕不育中心(达卡中央医院有限公司)进行,为期6年。已经经历了六个月自然超排卵周期或不孕持续时间超过一年的不孕夫妇被纳入研究范围。对不孕妇女进行评估,并对不孕原因进行评估。随访观察妊娠结局。结果:共招募790名女性。研究人群的平均年龄(标准差)为28.94±5.386岁。在790名不孕妇女中,12名妇女在IUI后怀孕。12例患者中有8例(66.7%)存在女性不孕因素,其余4例(33.3%)不存在。778例患者经IUI后不能怀孕,其中女性因素277例(35.6%),无女性不孕原因501例(64.4%)。女性因素的存在使IUI后不孕妇女的怀孕风险增加3.62倍(95% CI 1.08 ~ 12.12) (p=0.026)。790例不孕妇女中有285例(36.1%)存在女性不孕因素。结论:结论女性因素与宫内人工授精后不孕及其妊娠结局有显著关系。现代医学研究进展,2019;6(2):87-91
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Female Factors related with Infertility and Their Pregnancy Outcome after Intrauterine Insemination: Experience of 790 Cases in Bangladesh
Background: Several female factors are related with the cause of infertility. Objectives: The purpose of the present study was to assess female factors related with infertility and their pregnancy outcome after intrauterine insemination. Methodology: This prospective cohort study was carried out at a private infertility centre (Central Hospital Limited, Dhaka) in Dhaka city of Bangladesh from January 2012 to December 2017 for a period of 6 years. Infertile couples who already had undergone natural cycles of super-ovulation for six months or whose duration of infertility was more than one year were included. Infertile women were evaluated and the causes of infertility were assessed. The follow up was performed to see the pregnancy outcome. Result: A total number of 790 women were recruited. The mean age with standard deviation of study population was 28.94±5.386 years. Among 790 infertile women 12 women were become pregnant after IUI. Among these 12 women female factors of infertility was present in 8(66.7%) cases and the rest 4(33.3%) cases were absent. However, 778 women could not pregnant after IUI and among these 277(35.6%) cases had the presence of female factors and the rest 501(64.4%) cases had absence of female infertility causes. The presence of female factor had 3.62 (95% CI 1.08-12.12) times more risk to become pregnant among the infertile women after IUI (p=0.026). Among 790 infertile women 285(36.1%) women had presence of female infertility factors. Conclusion: In conclusion female factors are significantly related with infertility and their pregnancy outcome after intrauterine insemination. Journal of Current and Advance Medical Research 2019;6(2):87-91
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