经皮给药系统研究进展

D. Singh, Manoj Kumar Mishra
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引用次数: 0

摘要

在过去的三十年里,配方技术发生了巨大的变化和发展。药物输送系统的创新不仅与新剂型的开发有关,而且与使用现有药物进行治疗的新配方的开发有关。这些药物给药的创新具有许多优点,如更好的患者依从性,延长药物浓度的稳定状态,减少给药频率,药物靶向到预期的作用部位和低副作用。TDDS是为通过皮肤给药而设计的,它提供了控制和连续给药。它终止了药物在体循环中的脉冲进入,由此观察到副作用。这种经皮给药途径比口服给药途径更有利、更方便,提高了药物的安全性和有效性;它是一种对患者友好的无痛装置,可提供规范、统一的给药和持续的药物供应到目标部位,用于治疗各种疾病。
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A Recent Advance on Transdermal Drug Delivery System
From the past three decades there are huge changes and developments in formulation technology. Innovations in drug delivery systems are not only associated with the development of novel dosage forms but also with the development of new formulations using existing drugs for the treatment. These innovations in delivery of drug have many advantages like better patient compliance, maintenance of steady state concentration of drug for the prolong period, reducing dosing frequency, drug targeting to desired site of action and low side effects. TDDS are designed for delivery of drugs across the skin and it provides both controlled and continuous administration drug. It terminates the pulsed entry of drug in systemic circulation due to which side effects are observed. This transdermal route of drug delivery has more benefits and convenience than oral route and enhances the safety and efficacy of drug; it is patient friendly and painless device that provides regulated, uniform administration and the continuous supply of drug to targeted site for treatment of various diseases.
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