苯并咪唑l-核苷1263W94对更昔洛韦敏感和耐药人巨细胞病毒临床分离株的抑制作用

J. Mcsharry, Ann McDonough, B. Olson, C. Talarico, M. Davis, K. Biron
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引用次数: 47

摘要

1263W94和更昔洛韦对AD169的50%抑制浓度(IC50)分别为0.22±0.09 μM和5.36±0.12 μM。35株人巨细胞病毒(HCMV)临床分离株的平均IC50为0.42±0.09 μM 1263W94, 26株更昔洛韦敏感HCMV临床分离株的平均IC50为3.78±1.62 μM。9株对更昔洛韦耐药的HCMV临床分离株对1263W94完全敏感。
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Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole l-Riboside 1263W94
ABSTRACT The average 50% inhibitory concentration (IC50) values for AD169 were 0.22 ± 0.09 μM 1263W94 and 5.36 ± 0.12 μM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC50 was 0.42 ± 0.09 μM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC50 was 3.78 ± 1.62 μM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.
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