矩阵缓释片在NDDS系统中的研究进展

Sashank Shekhar, Alok Kumar, Vinod Rana, R. Kumar, Chavi Mittal, Kanchan Tariyal
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引用次数: 5

摘要

本分析的目的是根据它们所制成的聚合物的种类以及它们释放其内容物的速度对基质片进行分类。在医学应用方面,基质系统是有史以来开发的第一个口服缓释平台。利用基质片可以改变药物的释放特性。他们非常喜欢这种治疗因为他们给病人带来的好处是更好地坚持治疗,更稳定的药物水平,减少剂量和不良影响,以及更大的安全边际对于强效药物。由于亲水性聚合物基质系统在提供所需药物释放方面的通用性,成本低廉,以及一般的监管可接受性,因此经常用于口服控制药物递送剂型。由于溶解的药物通过亲水性凝胶网络迅速扩散,对于水溶性很强的药物,仅使用亲水性基质来延迟药物释放是不可能的。现在人们普遍认为,这类药物的配方需要使用含有疏水聚合物的基质系统。看来,最成功的策略是利用基质片剂制造一种口服控释制剂。
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Recent Approaches of Matrix Release Tablet in NDDS System
The purpose of this analysis is to categorize matrix tablets according to the kind of polymer they are made of as well as the rate at which they release their contents. When it came to medicinal applications, the matrix system was the very first oral extended release platform ever developed. The utilization of matrix tablets enables the modification of drug release characteristics. They are highly favored for this kind of treatment because of the benefits they give for the patient in terms of better adherence to the treatment, more stable medication levels, decreased dose and bad effects, and a bigger safety margin for highly potent medications. Because of their versatility in delivering a desired drug release profile, cheap cost, and general regulatory acceptability, hydrophilic polymer matrix systems are frequently used in oral controlled drug delivery dosage forms. Because of the rapid diffusion of the dissolved medication via the hydrophilic gel network, the use of hydrophilic matrix alone for delayed drug release is not possible for medicines that are very water soluble. It is now generally accepted that the formulation of such drugs requires the use of matrix systems that incorporate hydrophobic polymers. It would appear that the most successful strategy would be to create a formulation for oral controlled release by employing matrix tablets.
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