低密度脂蛋白作为治疗靶点

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE Clinica e Investigacion en Arteriosclerosis Pub Date : 2022-09-01 DOI:10.1016/j.arteri.2019.10.008
Ángel Díaz Rodríguez , Teresa Mantilla Morató
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引用次数: 0

摘要

在发达国家,动脉粥样硬化性心血管疾病(ASCVC)的发病率有所上升。血脂异常是ASCVD的主要危险因素,降低LDL是主要目标之一。尽管血脂异常的治疗目标应因人而异,但他汀类药物在ASCVD的一级和二级预防中具有成本效益。新的治疗方法具有更高的功效和更大的降低LDL, PSCK9抑制剂,在ASCVD治疗中取得了新的突破。2019年《血脂异常管理指南:脂质改变以降低心血管风险》(欧洲心脏病学会/欧洲动脉粥样硬化学会),其证据水平和建议的强度有助于在临床实践中为患者做出最佳决策和获益。
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LDL como objetivo terapéutico

The incidence of atherosclerotic cardiovsacular disease (ASCVC) has increased in the developed countries. Dyslipidemia is a primary major risk factor for ASCVD and LDL lowering is one of the main objectives. Although treatment goals for dyslipidemias should be personalized in every patient, statins are cost-effective in primary and secondary prevention of ASCVD. New treatments with higher power and greater decreases in LDL, PSCK9 inhibitors, have made a new breakthrough in ASCVD treatment. The 2019 Guidelines for de Management of Dyslipidaemias: Lipid Modification to reduce Cardiovascular Risk (European Society of Cardiology/European Atherosclerosis Society) with the level of evidence and the strength of the recommendations can facilitate the best decisions and benefits to our patients in clinical practice.

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来源期刊
Clinica e Investigacion en Arteriosclerosis
Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-
CiteScore
3.20
自引率
6.20%
发文量
44
审稿时长
40 days
期刊介绍: La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.
期刊最新文献
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