利用蛋白受体研究佛罗里达侧耳生物活性化合物的抗糖尿病活性

Beena Cherian, S. Jose
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引用次数: 0

摘要

糖尿病(DM)是由于胰岛素分泌缺陷(1型)和细胞对胰岛素抵抗增加(2型)引起的一种慢性代谢紊乱。蘑菇被发现对减少糖尿病并发症和降低血糖水平有效。与合成药物相比,从蘑菇中分离出的生物活性化合物似乎毒性更小,没有副作用。以佛罗里达侧耳菇乙醇提取物为原料,对其生物活性成分进行了提取。对化合物PFEE-1 ~ PFEE -14进行了药物相似性和分子性质的筛选。对于结构分子生物学和计算机辅助药物设计,分子对接被认为是一个强有力的工具。试图鉴定并阐明杏香菇中生物活性化合物抑制GPCR40、PTPBI、PPAR和DPP4蛋白受体控制血糖水平的作用机制。从杏叶菇乙醇提取物中筛选出14种生物活性化合物,并根据药物相似度评分与glide软件进行对接。与其他生物活性化合物相比,麦角甾醇是DPP4、GPCR40、PPAR和PTPBI的有效抑制剂。
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Antidiabetic Activity of Bioactive Compounds in Pleurotus florida using Protein Receptors
Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of Pleurotus florida mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in Pleurotus florida with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.
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