利用蛋白受体研究佛罗里达侧耳生物活性化合物的抗糖尿病活性

Beena Cherian, S. Jose
{"title":"利用蛋白受体研究佛罗里达侧耳生物活性化合物的抗糖尿病活性","authors":"Beena Cherian, S. Jose","doi":"10.21048/ijnd.2022.59.3.29578","DOIUrl":null,"url":null,"abstract":"Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of Pleurotus florida mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in Pleurotus florida with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.","PeriodicalId":22457,"journal":{"name":"The Indian journal of nutrition and dietetics","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antidiabetic Activity of Bioactive Compounds in Pleurotus florida using Protein Receptors\",\"authors\":\"Beena Cherian, S. Jose\",\"doi\":\"10.21048/ijnd.2022.59.3.29578\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of Pleurotus florida mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in Pleurotus florida with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.\",\"PeriodicalId\":22457,\"journal\":{\"name\":\"The Indian journal of nutrition and dietetics\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indian journal of nutrition and dietetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21048/ijnd.2022.59.3.29578\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indian journal of nutrition and dietetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21048/ijnd.2022.59.3.29578","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

糖尿病(DM)是由于胰岛素分泌缺陷(1型)和细胞对胰岛素抵抗增加(2型)引起的一种慢性代谢紊乱。蘑菇被发现对减少糖尿病并发症和降低血糖水平有效。与合成药物相比,从蘑菇中分离出的生物活性化合物似乎毒性更小,没有副作用。以佛罗里达侧耳菇乙醇提取物为原料,对其生物活性成分进行了提取。对化合物PFEE-1 ~ PFEE -14进行了药物相似性和分子性质的筛选。对于结构分子生物学和计算机辅助药物设计,分子对接被认为是一个强有力的工具。试图鉴定并阐明杏香菇中生物活性化合物抑制GPCR40、PTPBI、PPAR和DPP4蛋白受体控制血糖水平的作用机制。从杏叶菇乙醇提取物中筛选出14种生物活性化合物,并根据药物相似度评分与glide软件进行对接。与其他生物活性化合物相比,麦角甾醇是DPP4、GPCR40、PPAR和PTPBI的有效抑制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Antidiabetic Activity of Bioactive Compounds in Pleurotus florida using Protein Receptors
Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of Pleurotus florida mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in Pleurotus florida with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Characterization of Bio-Degradable Plant Based Film to Enhance the Shelf Life of Perishable Food Environmental Impact of Conventional Rice Cultivation using Life Cycle Analysis Standardisation and Quality Evaluation of Barnyard Millet Incorporated Probiotic Yoghurt Exploring Therapeutic Potential of Ginger: Preclinical and Clinical Review Current Information on Capsicum frutescens: A Critical Review of Pharmacological Potential
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1