合成可生物降解聚合物在受控药物输送系统中的应用综述

Amit Jagannath Gavasane, H. Pawar
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引用次数: 56

摘要

聚合物在给药领域中发挥着越来越重要的作用。聚合物的制药应用范围从片剂的粘合剂到液体、悬浮液和乳液中的粘度和流量控制剂。聚合物的使用现已扩展到控释和靶向给药系统。聚合物可以从天然来源获得,也可以通过化学方法合成。聚合物分为可生物降解和不可生物降解。生物可降解聚合物由于具有生物相容性和生物可降解性而广泛应用于生物医学领域。本文综述了目前在受控给药系统开发中应用的不同的可生物降解聚合物。
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Synthetic Biodegradable Polymers Used in Controlled Drug Delivery System: An Overview
Polymers are becoming increasingly important in the field of drug delivery. The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids, suspensions and emulsions. Use of polymer is now extended to controlled release and targeting drug delivery system. Polymers are obtained from natural source as well as synthesized chemically. Polymers are classified as biodegradable and nonbiodegradable. Biodegradable polymers have been widely used in biomedical applications because of their known biocompatibility and biodegradability. The present review gives an overview of the different biodegradable polymers that are currently being used in the development of controlled drug delivery system.
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