{"title":"LC-MS/MS用于动物异种代谢研究","authors":"L. Debrauwer","doi":"10.1051/ANALUSIS:2000280914","DOIUrl":null,"url":null,"abstract":"The use of LC-MS/MS in the identification of xenobic metabolism pathawys in animals is described, on the basis of selected examples in the field of toxixologically relevant growth promoting agents. The structural elucidation of xenobiotic metabollites in complex biological matrices is archieved using various analytical methods and strategies using LC-MS with ESI or APCI ionisation techniques in combination with in-source CAD or MS/MS experiments. The use of some particular analytical tools (e.g. H/D exchange or MSn multisequential experiments) for solving specific structural ambiguities is also discussed.","PeriodicalId":8221,"journal":{"name":"Analusis","volume":"28 1","pages":"914-920"},"PeriodicalIF":0.0000,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Use of LC-MS/MS for xenobiotic metabolism studies in animals\",\"authors\":\"L. Debrauwer\",\"doi\":\"10.1051/ANALUSIS:2000280914\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The use of LC-MS/MS in the identification of xenobic metabolism pathawys in animals is described, on the basis of selected examples in the field of toxixologically relevant growth promoting agents. The structural elucidation of xenobiotic metabollites in complex biological matrices is archieved using various analytical methods and strategies using LC-MS with ESI or APCI ionisation techniques in combination with in-source CAD or MS/MS experiments. The use of some particular analytical tools (e.g. H/D exchange or MSn multisequential experiments) for solving specific structural ambiguities is also discussed.\",\"PeriodicalId\":8221,\"journal\":{\"name\":\"Analusis\",\"volume\":\"28 1\",\"pages\":\"914-920\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analusis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1051/ANALUSIS:2000280914\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analusis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1051/ANALUSIS:2000280914","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Use of LC-MS/MS for xenobiotic metabolism studies in animals
The use of LC-MS/MS in the identification of xenobic metabolism pathawys in animals is described, on the basis of selected examples in the field of toxixologically relevant growth promoting agents. The structural elucidation of xenobiotic metabollites in complex biological matrices is archieved using various analytical methods and strategies using LC-MS with ESI or APCI ionisation techniques in combination with in-source CAD or MS/MS experiments. The use of some particular analytical tools (e.g. H/D exchange or MSn multisequential experiments) for solving specific structural ambiguities is also discussed.
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