Conjugated nanoconstructs of Dacarbazine for the treatment of metastatic melanoma

Cancer is the major reason of fatality worldwide. The global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2019 Nowadays incidence of . non-melanoma and melanoma skin cancers has mutually been increasing over the precedent couple of years. Among all types of cancer cases reported, the probability of occurrence of skin cancer is one in three according to Skin Cancer Foundation Statistics (SCF, 2017). According to WHO report 2019, approximately 3.5 million non-melanoma skin cancers and more than 140,000 melanoma skin cancers occur globally each year (WHO, 2019).