靶向慢性髓系白血病干细胞的策略

IF 3.9 Q2 ONCOLOGY Blood and Lymphatic Cancer-Targets and Therapy Pub Date : 2019-11-01 DOI:10.2147/BLCTT.S228815

Giovanna Carrá, A. Cartellà, B. Maffeo, A. Morotti

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引用次数: 1

摘要

慢性髓系白血病是一种由t(9;22)染色体易位编码嵌合蛋白BCR-ABL驱动的骨髓增殖性疾病。CML治疗代表了肿瘤分子治疗的典范。自BCR-ABL激酶酪氨酸激酶抑制剂的开发以来，CML的临床治疗方法发生了巨大变化，患者的生活质量和反应率都有了惊人的改善。然而，酪氨酸激酶抑制剂(TKIs)无法靶向CML中最不成熟的细胞成分，即CML干细胞，这一点仍然很清楚。本文综述了对TKIs耐药机制的新认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells

Abstract Chronic Myeloid Leukaemia is a myeloproliferative disorder driven by the t(9;22) chromosomal translocation coding for the chimeric protein BCR-ABL. CML treatment represents the paradigm of molecular therapy of cancer. Since the development of the tyrosine kinase inhibitor of the BCR-ABL kinase, the clinical approach to CML has dramatically changed, with a stunning improvement in the quality of life and response rates of patients. However, it remains clear that tyrosine kinase inhibitors (TKIs) are unable to target the most immature cellular component of CML, the CML stem cell. This review summarizes new insights into the mechanisms of resistance to TKIs.

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来源期刊

Blood and Lymphatic Cancer-Targets and Therapy ONCOLOGY-

自引率

7.10%

发文量

审稿时长

16 weeks

期刊介绍： Blood and Lymphatic Cancer: Targets and Therapy is an international, peer reviewed, open access journal focusing on blood and lymphatic cancer research, identification of therapeutic targets, and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for the cancer patient. Specific topics covered in the journal include: Epidemiology, detection and screening Cellular research and biomarkers Identification of biotargets and agents with novel mechanisms of action Optimal clinical use of existing anticancer agents, including combination therapies Radiation, surgery, bone marrow transplantation Palliative care Patient adherence, quality of life, satisfaction Health economic evaluations.