寄生虫病分子药物

Bhawana Singh
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摘要

寄生虫病是造成大量发病率和死亡率的原因,由于目前化疗的局限性,寄生虫病仍然是医疗界面临的主要挑战。药物发现/发明可以通过生物技术专家和药剂师的共同努力来实现,以确定潜在的候选药物,并成功地将其转化为改善医疗保健系统的药物。虽然分子医学在疾病干预方面仍处于起步阶段,但短时间内大量的研究工作和成功的试验使其在科学界得到了广泛的认可。随着生物信息学和组学领域的新技术进步,本章确定了处理寄生虫的不同分子医学方法。随着对基因组学的深入了解,分子医学领域不仅为应对寄生虫感染带来了希望,而且加速了个性化医疗的发展。这将为确定药物靶标及其对疾病干预的病理生理重要性提供一种有针对性的方法。
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Molecular Medicines for Parasitic Diseases
Being the cause for significant amount of morbidities and mortalities, parasitic diseases remain the major challenge for the healthcare community due to the limitations associated with the current chemotherapeutics. Drug discovery/invention can be achieved by collaborative efforts of biotechnologists and pharmacists for identifying potential candidates and successfully turn them into medicine for improving the healthcare system. Although molecular medicine for disease intervention is still in its infancy, however, significant research works and successful trials in short span of time have made it broadly accepted among the scientific community. This chapter identifies different molecular medicine approaches for dealing with parasites that have been coming up on the horizon with the new technological advances in bioinformatics and in the field of omics. With the better understanding of the genomics, molecular medicine field has not only raised hopes to deal with parasitic infections but also accelerated the development of personalized medicine. This will provide a targeted approach for identifying the druggable targets and their pathophysiological importance for disease intervention.
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