基于谷氨酰胺n -衍生物的含磷伪聚氨基酸软聚酯的合成及性能研究

IF 1 Q4 CHEMISTRY, MULTIDISCIPLINARY Chemistry & Chemical Technology Pub Date : 2022-02-20 DOI:10.23939/chcht16.01.051
A. Stasiuk, N. Fihurka, V. Vlizlo, S. Prychak, D. Ostapiv, S. Varvarenko, V. Samaryk
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引用次数: 4

摘要

聚磷酸酯(PPE)s是一类具有高化学功能和生物降解性的聚合物。采用Steglich反应合成了新型谷氨酸基聚磷酸酯。所开发的合成方法可以控制ppe的组成和结构,从而控制它们的物理和胶体性质。体外增溶性和细胞毒性的研究证明了ppe在给药方面的潜力。
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Synthesis and Properties of Phosphorus-Containing Pseudo-Poly(Amino Acid)sof Polyester Type Based on N-Derivatives of Glutaminic Acid
Poly(phosphoeter)s (PPE)s are a class of polymers possessing a high chemical functionality and biodegradability. Novel, glutamic acid based poly(phosphoeter)s were synthesized by the Steglich reaction. The developed synthetic approach allows controlling the composition and the structure of PPEs, and therefore their physical and colloidal properties. The studies on solubilization and cytotoxicity in vitro proved the potential of PPEs for drug delivery applications.
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来源期刊
Chemistry & Chemical Technology
Chemistry & Chemical Technology CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
1.70
自引率
44.40%
发文量
60
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