研究新席夫碱(R-CH=NAr)对雌性大鼠生殖激素的影响

Sheren Ali Hussien, K. Al-Fartosi
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引用次数: 0

摘要

本研究旨在探讨由樟脑和甘氨酸组成的化学碱(R-CH=N-Ar)对雌性大鼠生殖激素的影响。本研究选用24只wistar白化雌性大鼠,分为三组:第一组口服橄榄油作为对照组,第二组和第三组分别口服橄榄油溶希夫碱50 mg/kg和100 mg/kg,疗程21 d。结果显示,与对照组相比,第二组和第三组的黄体生成素水平没有受到希夫碱的影响,而第三组的FSH水平仅与第一组和第二组相比显著升高(p<0.05)。结果显示,与对照组相比,二、三组患者孕酮、雌激素水平显著升高(p<0.05),二、三组患者孕酮、雌激素水平差异无统计学意义。
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Study, to estimate the effect of new schiff base (R-CH=NAr) on the reproductive hormones of female Rats
The present study is designed to investigated the effect of prepared chemical base(R-CH=N-Ar)which consist of (camphr andglycin) on reproductive hormones of female rats.Twenty_fourwistar albino female ratsused  in this study, divided intothree groups: the first group was treated orally with olive oil as a control group, the second and third groups treated orally with schiff basedissolved in olive oilat two doses (50 mg/kg and 100 mg/kg) respectively for 21 day.The result showed that Schiff base did not affect level of LH hormone in second and third groups compared with control group while, FSH level increased significantly(p<0.05) in third group only compared with the first and second group. The result indicated a significant increase(p<0.05)in level of progesterone and estrogen hormones in seconedand third groups compared with the controlgroup, also non-signficant different in levels of both  hormones between second and third groups.
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