Purity of Plasma as a Sample for Neuropsychiatric Omics Studies Based on Virchow's Cellular Principle

As an idea to ensure the success of OMICS research, there is Virchow's pathological ideas of physical disease. This idea is that one cell, a group of cells, a substance, and a group of substances are specific for each disease. Based on this idea, it can be inferred that the unity and purity of the sample and the disease used are extremely important factors. In this study, the aim is to show how the difference in trivial centrifugal conditions of whole blood affected the plasma concentration of Phosphoethanolamine (PEA), a biomarker of depression shown in our previous study, It turned out that the value of PEA increases when the rotor is a swing type, or when the temperature at the time of centrifugation is set at 4°C. This increase might be due to platelet contamination in isolated plasma. Therefore, especially when the researchers are looking to discover an unknown marker, special attention should be paid to sample.