儿童流感疫苗接种后血凝抑制抗体滴度的双相减弱。

Weijia Xiong, T. Tsang, Ranawaka A.P.M Perera, Nancy H. L. Leung, V. Fang, I. Barr, J. Peiris, B. Cowling
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摘要

我们探索了流感疫苗接种后抗体滴度下降的双相模式的潜力。我们在一项儿童流感疫苗接种的随机对照试验中收集了血液样本,并用血凝抑制(HAI)检测甲型流感(H3N2)和乙型流感/维多利亚谱系。使用分段对数线性混合效应模型,我们发现证据表明,在接种疫苗后的最初1-2年,抗体滴度的初始下降速度更快,然后较慢的长期下降。接种后滴度较高的儿童抗体衰减较快。
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Biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children.
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children, and tested them with hemagglutination inhibition (HAI) assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effect models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher post-vaccination titers had faster antibody decay.
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