{"title":"用IMDA反应合成一种天然聚蜜苷类似物","authors":"Jean-François Betzer, Janick Ardisson, Ange Pancrazi","doi":"10.1016/S1387-1609(01)01260-9","DOIUrl":null,"url":null,"abstract":"<div><p>In our program of new macrocyclic antibiotic derivatives synthesis, a natural kijamicin analog was isolated, disclosing important antibiotic and antiviral properties, which are under investigation. In this paper we describe a synthesis of the bottom half C1-C14 (<em>n</em> = 1) of its aglycon. This strategy was based on the preparation of a tetraene derivative via a palladium catalyzed Stille coupling reaction, the final step involving an IMDA cyclization key step.</p></div>","PeriodicalId":100305,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","volume":"4 8","pages":"Pages 695-704"},"PeriodicalIF":0.0000,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01260-9","citationCount":"0","resultStr":"{\"title\":\"IMDA reaction in a synthetic approach towards a natural kijamicin aglycon analog\",\"authors\":\"Jean-François Betzer, Janick Ardisson, Ange Pancrazi\",\"doi\":\"10.1016/S1387-1609(01)01260-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In our program of new macrocyclic antibiotic derivatives synthesis, a natural kijamicin analog was isolated, disclosing important antibiotic and antiviral properties, which are under investigation. In this paper we describe a synthesis of the bottom half C1-C14 (<em>n</em> = 1) of its aglycon. This strategy was based on the preparation of a tetraene derivative via a palladium catalyzed Stille coupling reaction, the final step involving an IMDA cyclization key step.</p></div>\",\"PeriodicalId\":100305,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry\",\"volume\":\"4 8\",\"pages\":\"Pages 695-704\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1387-1609(01)01260-9\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1387160901012609\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387160901012609","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IMDA reaction in a synthetic approach towards a natural kijamicin aglycon analog
In our program of new macrocyclic antibiotic derivatives synthesis, a natural kijamicin analog was isolated, disclosing important antibiotic and antiviral properties, which are under investigation. In this paper we describe a synthesis of the bottom half C1-C14 (n = 1) of its aglycon. This strategy was based on the preparation of a tetraene derivative via a palladium catalyzed Stille coupling reaction, the final step involving an IMDA cyclization key step.
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