Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation

Objective: The aim of this study was to compare the swelling behaviour of HANP/PVA and HANP/PLGA/PVA composites. Material and Methods: This study was divided into 2 groups, HANP/ PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50C. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37C for 7 days (Ws). Statistical analysis based on Independent T-test (p<0.05). Results: The initial weight (Wi) of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The swollen weight (Ws) of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05). Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.