Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani
{"title":"隐绿原酸对伊拉克辣木叶乳腺癌细胞株MCF7的细胞毒性研究","authors":"Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani","doi":"10.32947/ajps.v22i2.837","DOIUrl":null,"url":null,"abstract":"\noleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. \n \nTherefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq\",\"authors\":\"Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani\",\"doi\":\"10.32947/ajps.v22i2.837\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\noleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. \\n \\nTherefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.\",\"PeriodicalId\":7406,\"journal\":{\"name\":\"Al Mustansiriyah Journal of Pharmaceutical Sciences\",\"volume\":\"76 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Al Mustansiriyah Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32947/ajps.v22i2.837\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Al Mustansiriyah Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32947/ajps.v22i2.837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq
oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities.
Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.