Н. Жданова, ' О.Б.Огарков, В. Синьков, ПЛ. Хромова, Е. А. Орлова, М. Е. Кощеев, Е. Д. Савилов, N. Zhdanova, O. Ogarkov, V. Sinkov, P. Khromova, E. Orlova, M. Koscheev, E. Savilov
{"title":"伊尔库茨克地区结核分枝杆菌北京基因型主要克隆分布的流行病学研究","authors":"Н. Жданова, ' О.Б.Огарков, В. Синьков, ПЛ. Хромова, Е. А. Орлова, М. Е. Кощеев, Е. Д. Савилов, N. Zhdanova, O. Ogarkov, V. Sinkov, P. Khromova, E. Orlova, M. Koscheev, E. Savilov","doi":"10.36233/0372-9311-2017-6-88-94","DOIUrl":null,"url":null,"abstract":"To the pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuber culosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were bom before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of СС 1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.","PeriodicalId":24020,"journal":{"name":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii","volume":"26 1","pages":"88-94"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"EPIDEMIOLOGICAL STUDY OF MAIN CLONES DISTRIBUTION GENOTYPE BEIJING OF MYCOBACTERIUM TUBERCULOSIS WITHIN IRKUTSK REGION\",\"authors\":\"Н. Жданова, ' О.Б.Огарков, В. Синьков, ПЛ. Хромова, Е. А. Орлова, М. Е. Кощеев, Е. Д. Савилов, N. Zhdanova, O. Ogarkov, V. Sinkov, P. Khromova, E. Orlova, M. Koscheev, E. Savilov\",\"doi\":\"10.36233/0372-9311-2017-6-88-94\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To the pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuber culosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were bom before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of СС 1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.\",\"PeriodicalId\":24020,\"journal\":{\"name\":\"Zhurnal mikrobiologii, epidemiologii, i immunobiologii\",\"volume\":\"26 1\",\"pages\":\"88-94\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhurnal mikrobiologii, epidemiologii, i immunobiologii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36233/0372-9311-2017-6-88-94\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36233/0372-9311-2017-6-88-94","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
EPIDEMIOLOGICAL STUDY OF MAIN CLONES DISTRIBUTION GENOTYPE BEIJING OF MYCOBACTERIUM TUBERCULOSIS WITHIN IRKUTSK REGION
To the pathogen in the Irkutsk region by comparison of genotypes of M. tuberculosis from patients of different age groups. Materials and methods. 588 epidemiologically unrelated strains of M. tuber culosis isolates from 567 ТВ patients were characterized using 24-locus MIRU-VNTR typing. 160 strains belonged to patients of different age groups. 59 strains were isolated from the «young» people with ТВ who were bom after 1990 and 101 isolates from people who were bom before 1955. Results. Two-thirds of the samples (427/567) were genotype Beijing with the dominance of two subtypes belonging to the modem epidemic clonal complexes CC1 and CC2. The high level of clustering profiles of СС 1 and CC2 genotype Beijing in «older» and «young» patients in the Irkutsk region indicates the presence and active transmission of epidemic CC1 and CC2 subtypes over the past fifty years.
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