寻找冠状病毒抑制剂的药物化学策略

Q3 Pharmacology, Toxicology and Pharmaceutics Acta pharmaceutica Sinica Pub Date : 2020-04-01 DOI:10.16438/J.0513-4870.2020-0131
Jing Li, Xiangyi Jiang, Shujing Xu, Q. Cui, Ruikun Du, Dongwei Kang, P. Zhan, L. Rong, Xin Liu
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引用次数: 0

摘要

冠状病毒引起的疫情对人类健康构成严重威胁,但目前尚无治疗此类病毒感染的特异性药物或疫苗。本文选取近年来的典型病例研究,从药物化学的角度综述了抗sars - cov、MERS-CoV等冠状病毒药物的药物化学策略,试图为当前抗sars - cov -2药物研究提供一些线索
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Medicinal chemistry strategies in seeking coronavirus inhibitors
The epidemic caused by coronavirus poses a serious threat to human health, but there is no specific drug or vaccine for the treatment of this kind of virus infection Herein, this article selects typical case studies in recent years and reviews the medicinal chemistry strategies of anti-SARS-CoV, MERS-CoV and other coronavirus drugs from the perspective of medicinal chemistry, and tries to provide some clues to current drug research against-SARS-CoV-2
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