氯胺酮麻醉对新生大鼠小脑平衡行为及组织病理学改变的影响

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摘要

氯胺酮是一种流行的药物,适用于各种人群,包括孕妇。值得注意的是,氯胺酮的大量使用可能导致疾病,尤其是神经系统疾病。本研究旨在探讨氯胺酮短期和长期反复麻醉对新生大鼠平衡行为和小脑组织变化的影响。方法:取雌性大鼠15只,雄性大鼠3只,随机分为对照组、长期组、短期组和氯胺酮重复麻醉组,每组5只。氯胺酮长期麻醉组妊娠雌鼠每周麻醉1次(剂量为75 mg/kg),氯胺酮短期和重复麻醉组妊娠雌鼠每周麻醉3次(剂量为25 mg/kg)。每周定期注射氯胺酮,直到怀孕结束。为了评价大鼠的平衡行为,在哺乳后对不同组的所有新生大鼠进行平衡行为测试。此外,在整个周期结束时进行组织采样。结果:长期用药组大部分组织改变与浦肯野层有关。在平衡性方面,不同组间在行走距离和滑倒次数上存在显著差异。结论:增加氯胺酮剂量对小脑组织有轻微影响,对平衡行为有明显影响。
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The Effect of Ketamine Anesthesia on Balance Behavior and Histopathological Changes of the Cerebellum in Rat Neonates
Introduction: Ketamine is a popular drug for use in various populations, including pregnant women. Of note, the high prevalence of ketamine use may cause disorders, especially in the nervous system. This study aimed to investigate the effect of repeated short-term and long-term anesthesia with ketamine on balance behavior and cerebellar tissue changes in neonatal rats. Method: In total, 15 female and 3 male rats were prepared and then randomly divided into 3 groups of 5 including control, long-term, as well as short-term and repeated anesthesia with ketamine. Pregnant female rats in the group of long-term anesthesia with ketamine were anesthetized once a week (at a dose of 75 mg/kg), and those in the groups of short-term and repeated anesthesia with ketamine were anesthetized 3 times a week (at a dose of 25 mg/kg). Ketamine injections were given weekly and regularly until the end of pregnancy. In order to evaluate the balance behavior of rats, a balance behavior test was conducted after lactation of all neonates of different groups. Moreover, tissue sampling was performed at the end of the whole period. Results: Most tissue changes were related to the Purkinje layer in the long-term group. In terms of balance, there were significant differences among different groups in terms of traveling distances and the number of slips. Conclusion: Increasing the dose of ketamine has mild effects on cerebellar tissue alongside significant effects on balance behavior.
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