Hideko Maeda, M. Katsushiro, H. Nariai, H. Nakayama
{"title":"环三磷酸法将磷酸基团引入β-熊果苷","authors":"Hideko Maeda, M. Katsushiro, H. Nariai, H. Nakayama","doi":"10.3363/PRB.33.21","DOIUrl":null,"url":null,"abstract":"Phosphorylation of -arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of -arbutin with P3m is -arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40oC. 4-Triphospho--arbutin was synthesized with the yield of 90%. The reaction mechanism of -arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated -arbutin is expected that the permeability of -arbutin into the skin will be increased by introducing a phosphate group. (Received Jul 7, 2017; Accepted Aug 2, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"5 1","pages":"21-25"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INTRODUCTION OF PHOSPHATE GROUP INTO β-ARBUTIN BY CYCLO-TRIPHOSPHATE\",\"authors\":\"Hideko Maeda, M. Katsushiro, H. Nariai, H. Nakayama\",\"doi\":\"10.3363/PRB.33.21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Phosphorylation of -arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of -arbutin with P3m is -arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40oC. 4-Triphospho--arbutin was synthesized with the yield of 90%. The reaction mechanism of -arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated -arbutin is expected that the permeability of -arbutin into the skin will be increased by introducing a phosphate group. (Received Jul 7, 2017; Accepted Aug 2, 2017)\",\"PeriodicalId\":20022,\"journal\":{\"name\":\"Phosphorus Research Bulletin\",\"volume\":\"5 1\",\"pages\":\"21-25\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phosphorus Research Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3363/PRB.33.21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phosphorus Research Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3363/PRB.33.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INTRODUCTION OF PHOSPHATE GROUP INTO β-ARBUTIN BY CYCLO-TRIPHOSPHATE
Phosphorylation of -arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of -arbutin with P3m is -arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40oC. 4-Triphospho--arbutin was synthesized with the yield of 90%. The reaction mechanism of -arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated -arbutin is expected that the permeability of -arbutin into the skin will be increased by introducing a phosphate group. (Received Jul 7, 2017; Accepted Aug 2, 2017)