{"title":"复杂生物系统建模:通过进化解决参数诅咒","authors":"P. Hogeweg","doi":"10.32942/osf.io/safm4","DOIUrl":null,"url":null,"abstract":"In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.","PeriodicalId":12324,"journal":{"name":"Evolutionary Systems Biology","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Modeling complex biological systems: Tackling the parameter curse through evolution\",\"authors\":\"P. Hogeweg\",\"doi\":\"10.32942/osf.io/safm4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.\",\"PeriodicalId\":12324,\"journal\":{\"name\":\"Evolutionary Systems Biology\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Evolutionary Systems Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32942/osf.io/safm4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evolutionary Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32942/osf.io/safm4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modeling complex biological systems: Tackling the parameter curse through evolution
In this perspective paper we review a previously published evolutionary model of the lac-operon to argue and demonstrate the importance of using evolutionary methods to derive relevant parameters. We show that by doing so we can debug experimental and modeling artifacts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
