低级别嗜瘤性肾肿瘤伴大量肝转移:不要相信CK7阴性和误诊嗜瘤性肾肿瘤:嗜瘤性肾肿瘤的警示和当前分类

IF 0.1 Q4 PATHOLOGY AJSP: reviews & reports Pub Date : 2022-03-01 DOI:10.1097/PCR.0000000000000491
A. Burke, T. Legesse, A. Paulk
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摘要

摘要我们报告一例肾肿瘤,最初诊断为嗜瘤细胞瘤,经活检证实多发性肝转移复发。最初的肿瘤复查显示主要是ck7阴性的肿瘤,有类似嗜酸性细胞瘤的区域,类似嗜酸性憎色肾细胞癌的区域,以及具有中间特征的区域。该病例说明嗜酸性憎色性肾细胞癌与“恶性潜能不确定的嗜酸细胞瘤”之间的区别在某些情况下是主观的。标准需要更好的定义,不应仅基于细胞角蛋白7染色模式。本文讨论了嗜酸性细胞性肾肿瘤的分类,并讨论了嗜酸性细胞质肾肿瘤的鉴别诊断。
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Low-Grade Oncocytic Renal Tumor With Massive Liver Metastasis: Do Not Trust a Negative CK7 and Misdiagnose Oncocytoma: A Cautionary Tale and Current Classification of Oncocytic Renal Tumors
Abstract We report a renal tumor originally diagnosed as oncocytoma that recurred with biopsy-proven multiple liver metastases. Review of the initial tumor revealed a predominantly CK7-negative neoplasm that had areas resembling oncocytoma, areas resembling eosinophilic chromophobe renal cell carcinoma, and areas with intermediate features. The case illustrates that the distinction between eosinophilic chromophobe renal cell carcinoma and “oncocytic tumor of uncertain malignant potential” is in some cases subjective. Criteria need better definition and should not be based on cytokeratin 7 staining pattern alone. A discussion of the current classification of oncocytic renal tumors is included, as well as a discussion of the differential diagnosis of renal neoplasms with eosinophilic cytoplasm.
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