抗结核治疗期间初始人β -防御素-1水平与患者生活质量的相关性

O. Shevchenko, O. Pohorielova
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摘要

背景。结核病患者的生活质量是治疗效果的重要组成部分。目标。目的:探讨抗结核治疗中初始人β -防御素-1 (HBD-1)水平与患者生活质量的相关性。材料和方法。100例肺结核患者被纳入研究。这些患者是根据目前的国家方案和世界卫生组织的指导方针进行诊断、治疗和监测的。此外,在治疗开始时,用ELISA法测定血浆中HBD-1的水平。在治疗开始、30天和60天后分别采用SF-25量表对患者进行访谈。评估身体功能、角色-身体功能、身体疼痛、一般健康、活力、社会功能、情感-角色功能和心理健康等参数。结果。我们发现HBD-1的初始水平与生活质量参数之间存在相关性:身体功能(-0.43),角色-身体功能(-0.34),身体疼痛(-0.23),一般健康(-0.42),社会功能(-0.42),情感-角色功能(-0.36);p < 0.05。所获得的负相关表明,高初始水平的HBD-1是治疗期间生活质量较低的预测因子。结论。治疗开始时HBD-1水平的升高可以被认为是肺结核患者治疗期间生活质量下降的预测因子。
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Correlations between initial human-beta-defensin-1 level and quality of life of patients during anti-tuberculosis therapy
Background. The quality of life of patients with tuberculosis is an important component of the treatment effectiveness. Objective. To find the correlations between initial human-beta-defensin-1 (HBD-1) level and quality of life of patients during anti-tuberculosis therapy. Materials and methods. 100 patients with pulmonary tuberculosis were included in the study. The patients were diagnosed, treated and monitored according to current state protocols and World Health Organization guidelines. Additionally, the level if HBD-1 was measured in blood plasma by ELISA at the treatment onset. The patients were interviewed using SF-25 scale at the treatment inset, after 30 days and after 60 days. The parameters of physical functioning, role-physical functioning, bodily pain, general health, vitality, social functioning, emotional-role functioning, and mental health were assessed. Results. We found correlations between the initial level of HBD-1 and quality of life parameters: physical functioning (-0.43), role-physical functioning (-0.34), bodily pain (-0.23), general health (-0.42), social functioning (-0.42), emotional-role functioning (-0.36); p<0.05. The obtained negative correlations indicate that a high initial level of HBD-1 is a predictor of lower quality of life during treatment. Conclusions. An increase in the level of HBD-1 at the treatment onset can be considered a predictor of a decrease in the quality of life during treatment in patients with pulmonary tuberculosis.
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