E. V. Kravchenko, L. M. Olgomets, O. N. Savanets, K. V. Borodina, E. S. Pustyulga, V. Golubovich, R. D. Zilberman, N. Bizunok, B. Dubovik
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Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test
The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.
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