用生物物理方法研究细胞穿透肽。

IF 7.2 2区 生物学 Q1 BIOPHYSICS Quarterly Reviews of Biophysics Pub Date : 2022-04-11 DOI:10.1017/S0033583522000026
Matjaž Zorko, Ülo Langel
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引用次数: 0

摘要

生物物理学研究对CPPs和CPP/cargo偶联物在活细胞或体内的内化、分子机制、相互作用和定位的理解具有非常重要的影响。生物物理研究通常首先在试管装置或体外进行,导致复杂的体内系统。本文综述了近年来关于CPP内化、机制和定位的研究。这些研究中的多种方法揭示了不同的新颖和重要的方面,并定义了CPP机制的规则,希望能够提高其对新颖和安全治疗的适用性。
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Studies of cell-penetrating peptides by biophysical methods.
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来源期刊
Quarterly Reviews of Biophysics
Quarterly Reviews of Biophysics 生物-生物物理
CiteScore
12.90
自引率
1.60%
发文量
16
期刊介绍: Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.
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