肿瘤干细胞的分子机制和调控途径

Zhen Wang, Hongwei Yang, Xin Wang, Liang Wang, Yingduan Cheng, Yongsheng Zhang, Y. Tu
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引用次数: 10

摘要

恶性癌症是危及生命的疾病之一,长期以来一直挑战着人类。传统的癌症治疗方法包括手术、化疗和放疗,目的是去除/摧毁癌细胞。虽然理论上很有希望,但这些方法都不能有效地根除癌症,其原因可以归结为我们对癌症转移和复发机制的认识不完全。近年来,研究人员提出了肿瘤干细胞(CSC)理论。CSC是一小群具有无限自我更新能力的肿瘤细胞,对化疗和放疗具有很强的抵抗力,已被证明是癌症转移和复发的核心原因。CSC理论为恶性肿瘤的发生提供了深刻的认识,为肿瘤治疗带来了新的希望。本文拟对CSC理论的发展进行综述,并对CSC起源和自我更新的调控途径进行综述,以期对未来恶性肿瘤治疗的发展有所帮助。
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The molecular mechanism and regulatory pathways of cancer stem cells
Malignant cancer is among the top of the life-threatening conditions, challenging humanity for a long time. Traditional methods of cancer therapy include surgery, chemotherapy, and radiotherapy, which aim to remove/destroy cancer cells. Although theoretically very promising, none of these methods can effectively eradicate cancer, the reason for which can be attributed to our incomplete understanding of the mechanism of cancer metastasis and recurrence. In recent years, researchers have proposed the theory of cancer stem cell (CSC). CSC is a small population of tumor cells that have unlimited self-renewal ability, exhibit a strong resistance to chemotherapy and radiotherapy, and have been proved to be the core reason of cancer metastasis and recurrence. CSC theory provides a deep insight into malignant tumorigenesis that brings new hope for tumor therapy. In this paper, we intend to discuss the development of CSC theory and summarize the regulatory pathways involved in CSC origin and self-renewal, which might be of assistance in the future development of malignant cancer therapy.
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