{"title":"过表达MDA-7/IL-24在甲状腺癌基因治疗中的作用","authors":"Mehri Hajikhan Mirzaei , Abdolreza Esmaeilzadeh","doi":"10.1016/j.jmhi.2013.06.002","DOIUrl":null,"url":null,"abstract":"<div><p>The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the prevalent treatments. Accumulated evidence suggests that interleukin-24 (IL-24), also known as melanoma differentiation-associated gene-7, has very important roles in regulation of cell differentiation, cell growth and apoptosis, and it is also a promising anticancer agent. Here, we propose that it could be advantageous to evaluate the anti-tumoural effect of IL-24 in a mouse xenograft model of thyroid cancer.</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"8 1","pages":"Pages 7-13"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2013.06.002","citationCount":"23","resultStr":"{\"title\":\"Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma\",\"authors\":\"Mehri Hajikhan Mirzaei , Abdolreza Esmaeilzadeh\",\"doi\":\"10.1016/j.jmhi.2013.06.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the prevalent treatments. Accumulated evidence suggests that interleukin-24 (IL-24), also known as melanoma differentiation-associated gene-7, has very important roles in regulation of cell differentiation, cell growth and apoptosis, and it is also a promising anticancer agent. Here, we propose that it could be advantageous to evaluate the anti-tumoural effect of IL-24 in a mouse xenograft model of thyroid cancer.</p></div>\",\"PeriodicalId\":100803,\"journal\":{\"name\":\"Journal of Medical Hypotheses and Ideas\",\"volume\":\"8 1\",\"pages\":\"Pages 7-13\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jmhi.2013.06.002\",\"citationCount\":\"23\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Hypotheses and Ideas\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2251729413000165\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Hypotheses and Ideas","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2251729413000165","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma
The annual incidence of thyroid cancer worldwide is alarming. Despite current various treatments such as surgical resection, radioiodine therapy and chemotherapy/radiotherapy, thyroid carcinoma remains a lethal cancer. Assuredly, the operative and new treatment strategies are necessary to control this malignancy. Gene therapy is regarded as one of the most reliable novel therapeutic methods for hopeless cases of thyroid cancer and those who do not respond to the prevalent treatments. Accumulated evidence suggests that interleukin-24 (IL-24), also known as melanoma differentiation-associated gene-7, has very important roles in regulation of cell differentiation, cell growth and apoptosis, and it is also a promising anticancer agent. Here, we propose that it could be advantageous to evaluate the anti-tumoural effect of IL-24 in a mouse xenograft model of thyroid cancer.
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