新发现的DEV UL53基因密码子使用偏向性的表征

Shunchuan Zhang, A. Cheng, Mingshu Wang
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引用次数: 3

摘要

本文对DEV的UL53基因的密码子使用偏向性进行了分析,结果表明该基因对位于第三位的A或T的同义密码子有较强的偏向性。采用EMBOSS程序和RSCU分析了DEV UL53基因和26种参比疱疹病毒的密码子使用偏向性。此外,系统进化树显示DEV在进化上更接近CaHV-2、CaHV-3、MeHV-1。C- gc3s图显示,疱疹病毒UL53基因的遗传异质性受第三密码子位置G+C含量的限制。结论:DEV UL53基因密码子使用偏倚程度与基因组成高度相关。通过SAS统计软件进行对应分析,表明酵母表达系统可能更适合于DEV基因的表达。
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Characterization of Codon Usage Bias in the Newly Identified DEV UL53 Gene
Codon usage bias in UL53 gene of DEV was analyzed in this paper, the results indicated that it had strong bias towards to the synonymous codons with A or T at the third codon position. The codon usage bias of DEV UL53 gene and 26 reference herpesviruses were analyzed by EMBOSS program and RSCU. In addition, Phylogenetic tree indicated DEV was evolutionarily closer to CaHV-2, CaHV-3, MeHV-1. The ENC-GC3S plot revealed that the genetic heterogeneity in UL53 gene of herpesviruses was constrained by G+C content at the third codon position. Conclusions: The extent of codon usage bias in the DEV UL53 gene was highly correlated with the gene composition. Analysis of correspondence through the SAS statistics software showed the yeast expression system might be more suitable for the expression of DEV genes.
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