微乳剂——新型给药系统的通用尺寸

P. Sudheer, K. Kar, C. Saha
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引用次数: 6

摘要

目的:综述了自微乳化给药系统的研究进展,以提高药物的溶出速度,从而提高药物的生物利用度。这种微乳技术既可用于输送亲水药物,也可用于输送亲脂药物。方法:在众多的方法中,微乳作为药物载体递送亲水性和亲脂性药物是一种成功的技术,因为它提高了药物的增溶能力,延长了保质期,易于制备和提高了生物利用度。综述了乳化的理论、制备微乳的方法、相图的重要性以及微乳的应用。研究发现:这种独特的光学透明、热力学稳定、通常粘度低的溶液被称为微乳液。微乳液粒径小于0.1µm。由于其独特的性能,如超低界面张力,大界面面积,热力学稳定性和溶解不混溶液体的能力,微乳液在制药领域的用途和应用已经很多。结论:本文综述了微乳技术作为新型给药系统成功维度之一的各种方法和应用。
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Microemulsion-a Versatile Dimension of Novel Drug Delivery System
Purpose: This article gives a general review on self-micro emulsifying drug delivery system which is used for increasing dissolution rate, thereby, achieving better bioavailability. This technique of microemulsion can be applied for delivery of hydrophilic as well as lipophilic drugs. Approach: Out of number of approaches, microemulsion is a successful technique for the delivery of hydrophilic as well as lipophilic drug as drug carriers because of its improved drug solubilization capacity, long shelf life, ease of preparation and improvement of bioavailability. A vast review on theories of emulsification, methods of achieving micro emulsion, importance of phase diagram and applications of micro emulsions have been illustrated. Findings: The unique classes of optically clear, thermodynamically stable and usually low viscous solution are called micro emulsions. Size of microemulsion is less than 0.1 µm. Due to their unique properties such as ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability to solubilize otherwise immiscible liquids, uses and applications of micro emulsions in pharmaceutical field have been numerous. Conclusion: This review covers a brief overview about various methods and applications of microemulsion technology as one of the successful dimension of novel drug delivery system.
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