Apoptosis-Induced Compensatory Proliferation in Cancer

Apoptosis is a biological process that allows adequate cellular turnover and the elimination of damaged or infected cells. However, there are compensatory molecular mechanisms that promote cell proliferation after increased apoptotic events. These events are commonly mediated by mitogenic proteins, released by apoptotic cells, and received by neighboring cells, that trigger mechanisms similar to cell repair after an injury or traumatic event. This Note to the Reader: This chapter is part of the book Metastasis (ISBN: 978-0-6453320-2-5), scheduled for publication in April 2022. The book is being published by Exon Publications , Brisbane, Australia, and edited by Professor Consolato M. Segi, MD, PhD, MPH, FRCPC, FCAP, Anatomic Pathology Division, Children's Hospital of Eastern Ontario, ON, Canada. This chapter was published under the Rapid Publication service. It effect is known as "apoptosis-induced proliferation". This chapter addresses the process of apoptosis-induced proliferation, the regulatory mechanisms, and its importance in cancer development, progression, and therapy development. protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene.