维生素A、C、D和锌对尿路感染的影响

Peng Gao, Wei-Yen Liang, Haimei Li, Lijia Guan, Qian Zhao, Dan Li
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引用次数: 1

摘要

尿路感染(UTI)在全球卫生保健总费用和死亡率中占很大一部分。我们检索了现有的研究来评估微量营养素补充剂是否会影响儿童尿路感染的频率和强度。研究维生素D和C、锌和多种微量营养素补充剂(MMS)对儿科患者尿路感染的发病率和严重程度的影响的论文汇集在一起。采用随机效应模型对数据进行meta分析。补充维生素D可以降低尿路感染的风险,缩短儿童症状的持续时间。如果使用临床诊断或实验室调查来确认尿路感染,维生素D与尿路感染的相对概率远低于使用自我报告。如果服用维生素C,尿路感染的频率减少,临床表现的时间缩短一半。不可能确定使用锌补充剂的影响。根据当前综述的结果,服用微量营养素补充剂,如锌、维生素C和D,以及多种微量营养素补充剂可以帮助预防尿路感染,并减少儿科患者的临床结果。需要更多的研究来确定单个或组合微量营养素对尿路感染治疗结果的影响。
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Effects of vitamins A, C, and D and zinc on urinary tract infections
Urinary tract infection (UTI) is responsible for a significant portion of the overall expenses of health care as well as mortality rates globally. We searched through the available research to evaluate whether micronutrient supplements affect the frequency and intensity of UTI in children Papers that investigated the effects of vitamins D and C, zinc, and multiple micronutrient supplementations (MMS) on the incidence and severity of UTI in pediatric patients were pooled together. A random effects model was used to conduct a meta-analysis of data. Vitamin D supplementation reduced the risk of UTI and shortened the duration of symptoms in children. If a clinical diagnosis or laboratory investigation was used to confirm UTI, the relative probability of UTI with vitamin D was remote from the null than using the self-report. If vitamin C was administrated, the frequency of UTI was reduced, and the period of clinical manifestations was cut to half. It was not possible to determine the impact of using zinc supplements. According to the findings of the current review, taking micronutrient supplements such as zinc, vitamins C and D, and multiple micronutrient supplementation could assist in preventing UTI and lessen its clinical outcome in pediatric patients. More research is required to establish the effect of individual or combination of micronutrients on the treatment outcomes of UTI.
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