血浆针治疗糖尿病足的替代方法

Q1 Medicine Clinical Plasma Medicine Pub Date : 2018-03-01 DOI:10.1016/j.cpme.2018.01.001
Régulo López-Callejas , Rosendo Peña-Eguiluz , Raúl Valencia-Alvarado , Antonio Mercado-Cabrera , Benjamín G. Rodríguez-Méndez , Jorge H. Serment-Guerrero , Agustín Cabral-Prieto , A. Concepción González-Garduño , N. Alberto Domínguez-Cadena , Jorge Muñoz-Infante , Mario Betancourt-Ángeles
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引用次数: 13

摘要

目的:本病例报道了氦冷等离子体治疗糖尿病足感染的替代疗法。方法采用0.025 l−1氦等离子针治疗3次,每次治疗前均对神经性溃疡进行手术清洗,治疗时间为180s。输出电抗器与线圈表面的距离在3 ~ 5 mm之间变化,同时等离子体剂量保持在0.42 W/cm2。结果1例确诊25年前的2型糖尿病女性患者,83岁,左脚慢性溃疡,采用冷血浆治疗。它被应用为大约10毫米位移的圆形运动,覆盖大约10毫米2的区域,并继续这个过程,直到完全覆盖伤口,试图在伤口的整个表面提供均匀的处理。结论伤口出现局部缺血,DEPA评分为10分,提示愈合预后差,甚至有截肢的危险。应用血浆为基础的治疗后,由于内皮细胞(血管生成的促进剂)的增殖增加,慢性伤口的愈合得到了促进。
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Alternative method for healing the diabetic foot by means of a plasma needle

Purpose

This case report deals with helium cold plasma as an alternative therapy for healing diabetic foot infections.

Methods

A surgical cleaning of neuropathic ulceration was performed before each one of three diary 0.025 Ls−1 helium plasma needle treatments with a duration in time of 180 s over the entire wound area. The distance between the output reactor and the wound surface varied between 3 and 5 mm, meanwhile the plasma dose was keept at 0.42 W/cm2.

Results

An 83-year-old female patient with diabetes mellitus type 2, diagnosed 25 years ago, presented with a chronic ulcer on the left foot was treated with cold plasma. It was applied as circular movements of approximately 10 mm displacement, covering an area of around 10 mm2 and continuing this procedure until completely covering the wound, trying to provide a uniform treatment over the entire surface of the wound.

Conclusion

The wound presented ischemia, and according to the classification DEPA had a score of 10, which implied a poor healing prognosis and even had the risk of amputation of the foot. After application of the plasma-based treatment the healing of the chronic wound was promoted due a higher proliferation of endothelial cells that are the promoters of angiogenesis.

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Clinical Plasma Medicine
Clinical Plasma Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
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