用于癌症治疗的氧化铁纳米颗粒表面工程

KC Barick, PA Hassan, S. Gawali, B. Dutta
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引用次数: 2

摘要

氧化铁纳米颗粒(IONPs)在生物医学领域有广泛的应用,如药物输送、医学诊断的磁共振成像(MRI)和癌症治疗。设计用于癌症治疗的高效离子螯合物需要用合适的具有多官能团的生物相容性有机和无机分子对其表面进行修饰。本文综述了离子内酰胺表面工程领域的最新进展及其在癌症治疗中的潜在应用。简要讨论了离子螯合蛋白与发光标记物和受体分子结合的成像和靶向潜力。
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Surface engineering of iron oxide nanoparticles for cancer therapy
Iron oxide nanoparticles (IONPs) have attracted extensive applications in biomedical fields such as drug delivery, magnetic resonance imaging (MRI) for medical diagnosis and cancer therapeutics. Designing efficient IONPs for cancer treatment requires their surface modification with suitable biocompatible organic and inorganic molecules having multifunctional groups. This review focuses on recent developments in the area of surface engineering of IONPs and their potential applications in cancer therapy. The imaging and targeting potential of IONPs in conjugation with luminescent markers and receptor molecules are briefly discussed.
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