Evaluation of antiulcer activity of Manilkara zapota (Linn) leaves extract in Wistar rats

Aim of the Study: The aim of the study was to evaluate the gastroprotective activity of Manilkara zapota leaf extract in Wistar rats. Materials and Methods: The leaf of M. zapota was air dried in the shade, powdered, and subjected to successive extraction in Soxhlet apparatus. The gastroprotective activity of the ethanol extract of M. zapota was evaluated using aspirin plus pylorus ligation and HCl plus ethanol-induced ulcer models. Results: Phytochemical analysis of various extracts of M. zapota revealed the presence of glycoside, flavonoid, tannins, and phenolic compounds. Ethanolic extract of M. zapota (EEMZ) extract treatment shows potent and effective gastroprotection against aspirin plus pylorus ligation and HCl plus ethanol-induced ulcer models. In pylorus-ligated rats, the extract decreases the secretion of pepsin, gastric acidity, volume, and increases gastric pH, glycoprotein, protein, superoxide dismutase, catalase, and non-protein sulfhydryl levels. In the HCl plus ethanol-induced rats, the EEMZ treatment significantly increased the prostaglandin secretion and protects the gastric mucosa compared to the control group rats. Conclusion: The results of the study showed that EEMZ possesses a preventive effect against gastric ulcer model in the experimental animals.