纳米医学(g)诊断与化学:富有成效的二项研究

M. Valcárcel
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引用次数: 2

摘要

这篇前瞻性文章的主要目的是让化学家们认识到纳米医学这一新兴医学分支的巨大潜力,以及他们在跨学科的氛围中可以在这一有前途的主题中发挥的关键作用。纳米医学领域的纳米治疗(g)诊断的现状和未来的情况,在这篇小型综述中,通过提炼这一相对较新的热点话题的最相关的见解,批判性地提出和讨论。在它的语境化之后,更新的一般纳米(g)的噪音处理。根据几种分类标准,报告了参与这一过程的最常见的治疗(g)药物以及纳米治疗(g)过程的主要类型。简要介绍了纳米疗法(g)在几种相关疾病中的潜在影响。概述了化学在纳米治疗的两个瓶颈中的关键作用,即分离载体纳米治疗剂和共轭纳米治疗纳米颗粒的合成以及(生物)化学分析(即质量保证,合成过程的监测和最终药物的表征)。最后,对这一新兴的纳米技术的未来进行了一些思考。
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Nanothera(g)nosis and Chemistry: A Fruitful Binomial
The main purpose of this perspective article is to open the eyes of chemists to the great potential of Nanothera(g) nosis, an emerging branch in Medicine, and the crucial roles that they can play in this promising topic in an interdisciplinary atmosphere. The present and future situation of Nanothera(g)nosis in the Nanomedicine field are critically presented and discussed in this minireview by distilling the most relevant insights of this relatively recent but hot topic. After a contextualization of it, the updated generalities of Nanothera(g)nosis are deal with. The most frequent thera(g)noastic agents participating in this process as well as the main types of Nanothera(g)nosis processes according to several classification criteria are reported. A brief description of the potential impact of Nanothera(g)nosis in several relevant diseases are also presented. The crucial roles of Chemistry in the two bottle-necks of Nanothera(g)nosis namely the synthesis of isolated carrier nanothera(g)nositc agents and conjugated nanothera(g)nostic nanoparticles as well as the (bio)chemical analysis (i.e. quality assurance, monitoring of synthetic procedures and the characterization of final pharmaceutical drug) are outlined. Finally, some author´s reflections about the future of this emerging nanotechnology included.
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