纳米颗粒-局部给药的范例

Yogesh S. Chaudhari
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引用次数: 10

摘要

由于难以控制活性药物成分(API)在皮肤内的命运,局部药物递送仍然是一个挑战。由于成分材料的安全性和可控释放能力,纳米颗粒为药物的合理递送提供了极好的机会,因此这些载体系统有效地用于药物和化妆品目的的各种活性成分的局部递送。近年来,固体脂质纳米颗粒(SLNs)作为外用活性物质的载体显示出巨大的潜力,主要是由于其可能的靶向作用和在不同皮肤层的控释。此外,纳米结构脂质载体(nlc)是一种新型的局部给药系统,在药物负载和长期稳定性方面具有改进的性能,能够形成高度浓缩的分散体。局部给药领域的另一项发明是使用胶束纳米颗粒(MNPs),它通过使用已经被证明安全有效的药物来创建新的专有配方,提供了一种潜在的快速和廉价的药物开发模式。这些新型药物输送系统结合了脂质科学和纳米科学技术,因此可能是更好的替代载体,因此引起了人们的极大兴趣。
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Nanoparticles - A paradigm for topical drug delivery
Topical drug delivery is still a challenge due to the difficulties in controlling the active pharmaceutical ingredient (API) fate within the skin. Due to the safety of the component material and controlled release abilities, nanoparticles offer an excellent opportunity for the rational delivery of drugs to the desired target site and hence these carrier systems are effectively used for topical delivery of variety of active principles for both pharmaceutical as well as cosmetic purposes. Recently, solid lipid nanoparticles (SLNs) have shown a great potential as carriers for topical administration of active substances, principally owing to the possible targeting effect and controlled release in different skin strata. Also, nanostructured lipid carriers (NLCs) are a new type of topical delivery system offering improved performance in terms of drug loading and long-term stability with the ability to form highly concentrated dispersions. Another invention in the field of topical drug delivery is the use of micellar nanoparticles (MNPs) that offer a potentially fast and inexpensive pharmaceutical development model by using drugs already proven safe and effective to create new proprietary formulations. These novel drug delivery systems have gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers.
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