冬眠觉醒时骨骼肌肌浆网脂肪酰基组成的改变

Daniel J. Pehowich
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引用次数: 10

摘要

对冬眠和觉醒的理查森地鼠骨骼肌肌浆网脂肪酰基组成进行了分析。唤醒动物的磷脂酰胆碱(PC)、磷脂酰乙醇胺(PE)和磷脂酰肌醇(PI)部分中单不饱和脂肪酰基总水平升高。二十二碳六烯酸(22:6n-3)在所有磷脂中都较低,而20:42:6的比例在觉醒动物中较高。脂肪酰基组成的这些变化有可能改变SR Ca2+- atp酶活性和Ca2+摄取效率,在能量要求高的觉醒过程中。
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Modification of skeletal muscle sarcoplasmic reticulum fatty acyl composition during arousal from hibernation

The fatty acyl composition of sarcoplasmic reticulum was analyzed in skeletal muscle from hibernating and aroused Richardson's ground squirrels, Spermophilus richardsonii.

Total levels of monounsaturated fatty acyl groups increased in the phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) fractions of aroused animals. Docosahexaenoic acid (22:6n-3) was lower in all phospholipids while the ratio 20:422:6 was higher in aroused animals.

These changes in fatty acyl composition have the potential to alter SR Ca2+-ATPase activity and Ca2+ uptake efficiency during the energetically demanding arousal process.

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