{"title":"保护心脏","authors":"Mark T. Nelson","doi":"10.1126/scisignal.1572002tw405","DOIUrl":null,"url":null,"abstract":"Within the mitochondria of heart cells, ion channels control the flux of different ions and change the physiological status of the mitochondria, which in turn affect the relative health of the heart cell. Xu et al. now describe the role of a calcium-activated potassium channel in the inner mitochondrial membrane of guinea-pig heart cells in protecting the cells from ischemia. A drug that opened the channel could protect the heart from infarction. W. Xu, Y. Liu, S. Wang, T. McDonald, J. E. Van Eyk, A. Sidor, B. O'Rourke, Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science 298, 1029-1033 (2002). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"84 1","pages":"TW405 - tw405"},"PeriodicalIF":0.0000,"publicationDate":"2002-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Protecting the Heart\",\"authors\":\"Mark T. Nelson\",\"doi\":\"10.1126/scisignal.1572002tw405\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Within the mitochondria of heart cells, ion channels control the flux of different ions and change the physiological status of the mitochondria, which in turn affect the relative health of the heart cell. Xu et al. now describe the role of a calcium-activated potassium channel in the inner mitochondrial membrane of guinea-pig heart cells in protecting the cells from ischemia. A drug that opened the channel could protect the heart from infarction. W. Xu, Y. Liu, S. Wang, T. McDonald, J. E. Van Eyk, A. Sidor, B. O'Rourke, Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science 298, 1029-1033 (2002). [Abstract] [Full Text]\",\"PeriodicalId\":21619,\"journal\":{\"name\":\"Science's STKE\",\"volume\":\"84 1\",\"pages\":\"TW405 - tw405\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science's STKE\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1126/scisignal.1572002tw405\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1572002tw405","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
摘要
在心脏细胞的线粒体内，离子通道控制不同离子的通量，改变线粒体的生理状态，进而影响心脏细胞的相对健康。Xu等人现在描述了豚鼠心脏细胞线粒体内膜中钙活化的钾通道在保护细胞免受缺血中的作用。一种打开通道的药物可以防止心脏梗塞。徐伟，刘玉英，王淑娟，王志强，王志强，王志强，王志强，J. E. Van Eyk, A. Sidor, B. O'Rourke，钙离子激活的K+通道在心肌线粒体内膜的细胞保护作用。科学29,1029-1033(2002)。【摘要】【全文】
Within the mitochondria of heart cells, ion channels control the flux of different ions and change the physiological status of the mitochondria, which in turn affect the relative health of the heart cell. Xu et al. now describe the role of a calcium-activated potassium channel in the inner mitochondrial membrane of guinea-pig heart cells in protecting the cells from ischemia. A drug that opened the channel could protect the heart from infarction. W. Xu, Y. Liu, S. Wang, T. McDonald, J. E. Van Eyk, A. Sidor, B. O'Rourke, Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science 298, 1029-1033 (2002). [Abstract] [Full Text]
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