A Review on Osmotic Drug Delivery System

Conventional drug delivery systems have slight control over their drug release and nearly uncontrollable over the effective concentration at the target site. This type of dosing pattern might effect on constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled design over a prolonged period of time by the controlled or modified release drug delivery systems. For most of the drugs, oral route is the most tolerable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Evolution of an extended-release dosage form also need sensible absorption throughout the gastro-intestinal tract (GIT). Among the existing techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most suitable one. Osmotic drug delivery systems release the drug with the zero-order kinetics at a constant rate. This review brings out advantages, disadvantages, principles, basic components and classification of osmotic drug delivery systems.