甲状腺乳头状癌临床生物学及病理特征分析

Ying Li, Yimin Su, Rongqin Dai, F. Zhou, Chao Shen, Zhongzhou Su, Guiqiang Yang
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摘要

甲状腺乳头状癌是临床上最常见的甲状腺肿瘤之一。甲状腺乳头状癌的发病率逐年上升,尤其是沧州地区,给患者带来极大的身心痛苦。目的:通过对甲状腺乳头状癌的生物学及临床病理特点的分析,进一步加强认识,提高诊治水平。方法:收集住院的甲状腺乳头状癌患者,分析其生物学和病理特征。结果:110例甲状腺乳头状癌中,男性11例(10%),女性99例(90%)。在浸润性、淋巴结转移、乳头状微癌比例、病变数及累及腺叶方面,按不同年龄、性别分组差异无统计学意义(P>0.05)。有侵袭的46例患者平均年龄小于无侵袭的患者(P<0.001)。乳头状微癌侵袭及淋巴结转移较少(P<0.001)。16例桥本甲状腺炎患者为女性,平均发病年龄较高,差异有统计学意义(P<0.001), TSH水平也高于非桥本甲状腺炎患者(P<0.05)。结论:甲状腺乳头状癌的临床病理特征在不同年龄组和性别组间无显著差异,但在侵袭性研究中,侵袭性患者的平均年龄较低。乳头状微癌患者较少发生浸润和淋巴结转移。桥本甲状腺炎患者TSH水平普遍较高。
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The Analysis of Clinical Biological and Pathological Features in Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: The understanding is further strengthened, and the level of diagnosis and treatment is improved, through the analysis of the biological and clinicopathological characteristics of papillary thyroid carcinoma. Method: Hospitalized cases with papillary thyroid carcinoma were collectedand biological and pathological characteristics were analyzed. Result: Among 110 cases of papillary thyroid carcinoma, 11 cases were male (10%), 99 cases were female (90%). There was no significant difference in invasiveness, lymph node metastasis, proportion of papillary microcarcinoma, number of lesions and involvement of glandular lobe, which were divided into groups according to different ages and different genders, (P>0.05). The average age of 46 cases with invasion was younger than that without invasion (P<0.001). There was less invasion and lymph node metastasis in papillary microcarcinoma (P<0.001). 16 cases of Hashimoto's thyroiditis were female, the average age of onset was higher, the difference was statistically significant (P<0.001) and TSH level was also higher than the patients without Hashimoto's thyroiditis (P<0.05). Conclusion: There was no significant difference in the clinicopathological characteristics of papillary thyroid carcinoma in different age groups and gender groups, but in the invasive study, the average age of patients with invasion was lower. Patients with papillary microcarcinoma are less likely to have invasion and lymph node metastasis. TSH levels are generally high in patients with Hashimoto's thyroiditis.
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